Kondo M, Ishifuji K, Tsuchiya K, Goto S, Kuwahara S
Antimicrob Agents Chemother. 1973 Aug;4(2):156-9. doi: 10.1128/AAC.4.2.156.
The in vivo protecting activity of 9-propionylmaridomycin, a derivative of the new macrolide antibiotic, maridomycin, was compared with that of other macrolide antibiotics in mice infected with Staphylococcus aureus, Streptococcus pyogenes, and Diplococcus pneumoniae. The protective effect was almost similar to that afforded by several known macrolide antibiotics in mice infected intraperitoneally with certain strains of the gram-positive species described above. The skin lesion caused by intradermal challenge of S. aureus in mice also responded very effectively to treatment with 9-propionylmaridomycin.
新型大环内酯类抗生素马立霉素的衍生物9-丙酰马立霉素，在感染金黄色葡萄球菌、化脓性链球菌和肺炎双球菌的小鼠体内，其保护活性与其他大环内酯类抗生素进行了比较。在经腹腔感染上述某些革兰氏阳性菌菌株的小鼠中，其保护效果与几种已知大环内酯类抗生素几乎相似。小鼠经皮内注射金黄色葡萄球菌引起的皮肤损伤，对9-丙酰马立霉素治疗也有非常有效的反应。
