Burghardt R C, Anderson E
J Cell Biol. 1979 Apr;81(1):104-14. doi: 10.1083/jcb.81.1.104.
Thin-section and freeze-fracture studies on the rat ovarian interstitial cells revealed reductions in the size and the number of gap junctions after pituitary ablation. Small gap junctions, however, persist as long as 90 days after hypophysectomy even though regressive cytoplasmic changes are completed 75 d earlier. Administration of exogenous human chorionic gonadotrophin (HCG) results in the restoration of the normal interstitial cell morphology which is accompanied by amplification of junctional membrane. Within 24 h of hormone application, gap junction growth is characterized by the appearance of formation plaques. These studies suggest that the effect of hormone on interstitial cell gap junctions is to modulate the junctional surface area.
对大鼠卵巢间质细胞进行的薄切片和冷冻断裂研究显示,垂体切除后间隙连接的大小和数量减少。然而,即使在垂体切除75天前细胞质的退行性变化已经完成,小的间隙连接在垂体切除后长达90天仍持续存在。给予外源性人绒毛膜促性腺激素(HCG)可使间质细胞形态恢复正常,同时伴有连接膜的扩增。在应用激素后的24小时内,间隙连接的生长表现为形成斑的出现。这些研究表明,激素对间质细胞间隙连接的作用是调节连接表面积。