Scherer U, Santos M, Lissner J
J Comput Assist Tomogr. 1979 Oct;3(5):589-95. doi: 10.1097/00004728-197910000-00003.
Eighty-two liver specimens were studied by both computed tomography (CT) and pathological examination with serial sectioning. In vitro CT studies showed low density structures within 57 normal livers to be due to portal and hepatic vessels but not to bile ducts. A liver with a minimum of 70% fatty infiltration could be diagnosed correctly on CT. Concerning the presence or absence of circumscribed liver disease, sensitivity was 80% and specificity was 84%. With respect to the total number of space occupying liver lesions (n = 364 in 18 specimens), sensitivity was 72%. The smallest metastases detectable on CT were 0.5 cm in diameter, but CT disclosed focal lesions of this small size in only 15% of the cases. In contrast to previously reported in vivo CT studies, metastases were often found to be of higher density than normal liver tissue in vitro.
82个肝脏标本同时接受了计算机断层扫描（CT）检查和病理连续切片检查。体外CT研究显示，57个正常肝脏内的低密度结构是由门静脉和肝血管而非胆管所致。CT能够正确诊断出脂肪浸润率至少为70%的肝脏。对于局限性肝病的有无，敏感性为80%，特异性为84%。就肝脏占位性病变的总数（18个标本中有364个）而言，敏感性为72%。CT可检测到的最小转移灶直径为0.5厘米，但CT仅在15%的病例中发现了如此小尺寸的局灶性病变。与先前报道的体内CT研究不同，体外研究中经常发现转移灶的密度高于正常肝组织。
