Maddin W S, Wood W S
J Cutan Pathol. 1979 Apr;6(2):96-100. doi: 10.1111/j.1600-0560.1979.tb01109.x.
A report on four patients with psoriasis who have developed multiple keratoacanthomas and squamous cell carcinoma at the treatment sites is presented. Two other reports have appeared in the literature which link the development of keratoacanthoma with psoriasis and pustular psoriasis. Although a number of etiologic factors have been suspected for the development of these new growths, this presentation will further assess the specific roles that treatment measures may have played in these cases. Furthermore, the significance of impaired cellular immune defense mechanisms will be discussed.
本文报告了4例银屑病患者在治疗部位发生多发性角化棘皮瘤和鳞状细胞癌的情况。文献中还出现了另外两篇将角化棘皮瘤的发生与银屑病和脓疱型银屑病联系起来的报告。尽管对于这些新生长物的发生怀疑有多种病因，但本报告将进一步评估治疗措施在这些病例中可能发挥的具体作用。此外，还将讨论细胞免疫防御机制受损的意义。
