Ziegels J
J Hirnforsch. 1979;20(1):11-8.
Since morphological data do not allow to draw conclusions concerning the phyletic evolution of the subcommissural organ (SCO), a "metabolic" criterion is considered. Histoenzymology permits a comparison of metabolic activity in the subcommissural organ and that found within the ependyma. During the course of phyletic evolution, one notes various changes. Indeed, in lower vertebrates, the SCO presents a greater degree of enzyme activity than the ependyma while in birds the ependyma demonstrates a more intense activity than the SCO. The results are also compared with those previously reported in reptiles and mammals. In all vertebrates, glucid catabolism seems predominent in this areas.
由于形态学数据无法就连合下器官（SCO）的系统发育进化得出结论，因此考虑采用一种“代谢”标准。组织酶学可以对连合下器官和室管膜内的代谢活性进行比较。在系统发育进化过程中，可以观察到各种变化。实际上，在低等脊椎动物中，SCO的酶活性程度高于室管膜，而在鸟类中，室管膜的活性比SCO更强。研究结果还与先前在爬行动物和哺乳动物中报道的结果进行了比较。在所有脊椎动物中，糖类分解代谢似乎在这些区域占主导地位。
