轴突的非线性电缆方程。II. 外部电流电极的计算与实验
Nonlinear cable equations for axons. II. Computations and experiments with external current electrodes.
作者信息
Moore J W, Arispe N J
出版信息
J Gen Physiol. 1979 Jun;73(6):737-45. doi: 10.1085/jgp.73.6.737.
Abstract
We have investigated the steady-state potential and current distributions resulting from current injection into a close-fitting channel into which a squid axon is placed. Hybrid computer solutions of the cable equations, using the Hodgkin-Huxley equations to give the membrane current density, were in good agreement with experimental observations. A much better fit was obtained when the Hodgkin-Huxley leakage conductance was reduced fivefold.
摘要
我们研究了将电流注入放置有鱿鱼轴突的紧密贴合通道时所产生的稳态电位和电流分布。利用霍奇金-赫胥黎方程来给出膜电流密度，通过对电缆方程进行混合计算机求解，所得结果与实验观测结果吻合良好。当霍奇金-赫胥黎漏导降低五倍时，拟合效果要好得多。
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引用本文的文献
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Nonlinear cable equations for axons. I. Computations and experiments with internal current injection.轴突的非线性电缆方程。I. 内部电流注入的计算与实验。
J Gen Physiol. 1979 Jun;73(6):725-35. doi: 10.1085/jgp.73.6.725.
本文引用的文献
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A quantitative description of membrane current and its application to conduction and excitation in nerve.膜电流的定量描述及其在神经传导和兴奋中的应用。
J Physiol. 1952 Aug;117(4):500-44. doi: 10.1113/jphysiol.1952.sp004764.
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Nonlinear cable equations for axons. I. Computations and experiments with internal current injection.轴突的非线性电缆方程。I. 内部电流注入的计算与实验。
J Gen Physiol. 1979 Jun;73(6):725-35. doi: 10.1085/jgp.73.6.725.
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