鱿鱼轴突钠电导系统的动力学模型。
A kinetic model for the sodium conductance system in squid axon.
作者信息
Moore J W, Cox E B
出版信息
Biophys J. 1976 Feb;16(2 Pt 1):171-92. doi: 10.1016/s0006-3495(76)85673-1.
Abstract
We describe a kinetic reaction sequence for the sodium conductance system in the squid axon. It closely matches the original Hodgkin and Huxley model for voltage clamp experiments but it generates an action potential without a bump on the falling phase. When calcium ions are included in the reaction, this model faithfully reproduces the experimental observations of Frankenhaeuser and Hodgkin on the effects of altered calcium in the medium. The fit to experiment is much better than when a voltage shift in rate constants is assumed. The gating currents recently observed by Armstrong and Bezanilla are not compatible with the Hodgkin and Huxley model but can be reprocuced in considerable detail by the kinetic model. Thus it appears that the kinetic model differs from that of Hodgkin and Huxley perhaps in an important and fundamental way that makes it more realistic.
摘要
我们描述了枪乌贼轴突中钠电导系统的动力学反应序列。它与用于电压钳实验的原始霍奇金和赫胥黎模型非常匹配，但它产生的动作电位在下降阶段没有凸起。当反应中包含钙离子时，该模型如实地再现了弗兰肯海默和霍奇金关于介质中钙改变的影响的实验观察结果。与假设速率常数存在电压偏移时相比，该模型与实验的拟合要好得多。阿姆斯特朗和贝扎尼拉最近观察到的门控电流与霍奇金和赫胥黎模型不兼容，但动力学模型可以相当详细地再现这些电流。因此，动力学模型似乎与霍奇金和赫胥黎的模型有所不同，也许在一个重要且基本的方面使其更符合实际情况。
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本文引用的文献
1
Ion movements during nerve activity.神经活动期间的离子运动。
Ann N Y Acad Sci. 1959 Aug 28;81:221-46. doi: 10.1111/j.1749-6632.1959.tb49311.x.
2
GATE CONTROL OF ION FLUX IN AXONS.轴突中离子通量的门控
J Gen Physiol. 1965 May;48(5):SUPPL:75-7. doi: 10.1085/jgp.48.5.75.
3
A MOLECULAR STRUCTURAL BASIS FOR THE EXCITATION PROPERTIES OF AXONS.轴突兴奋特性的分子结构基础
Biophys J. 1964 May;4(3):167-88. doi: 10.1016/s0006-3495(64)86776-x.
4
THE SQUID GIANT AXON. MATHEMATICAL MODELS.乌贼巨大轴突。数学模型。
Biophys J. 1963 Sep;3(5):399-431. doi: 10.1016/s0006-3495(63)86829-0.
5
The action of calcium on the electrical properties of squid axons.钙对鱿鱼轴突电特性的作用。
J Physiol. 1957 Jul 11;137(2):218-44. doi: 10.1113/jphysiol.1957.sp005808.
6
The binding of tetrodotoxin to nerve membranes.河豚毒素与神经膜的结合。
J Physiol. 1971 Feb;213(1):235-54. doi: 10.1113/jphysiol.1971.sp009379.
7
Molecular mechanisms of membrane ionic permeability changes.
Biochim Biophys Acta. 1971 Jan 5;225(1):1-10. doi: 10.1016/0005-2736(71)90277-x.
8
Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons.乌贼轴突中季铵离子注入引起的钾离子电导失活及相关现象。
J Gen Physiol. 1969 Nov;54(5):553-75. doi: 10.1085/jgp.54.5.553.
9
Interpretation of the sodium permeability changes of myelinated nerve in terms of linear relaxation theory.
J Theor Biol. 1971 Oct;33(1):77-89. doi: 10.1016/0022-5193(71)90217-7.
10
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