Fekete M I, Herman J P, Kanyicska B, Palkovits M
J Neural Transm. 1979;45(3):207-18. doi: 10.1007/BF01244409.
Noradrenaline (NA), dopamine (DA) and DOPAC were determined with a newly developed radioenzymatic method simultaneously in the striatum, limbic system, hypothalamus and in catecholamine-containing cell groups of the rat brain. Only a loose relationship could be established between DOPAC and DA contents in the various brain areas. The lowest relative DOPAC level (DOPAC/DA ratio) was found in the median emience, while it was the highest in the periventricular nucleus of the hypothalamus. Haloperidol increased the DOPAC level in only part of the nuclei examined (striatum, olfactory tubercle, central amygdaloid nucleus), while in other limbic regions as well as in the hypothalamic dorsomedial, arcuate and paraventricular nuclei it proved to be ineffective. The DOPAC level in the locus coeruleus was decreased by haloperidol. Pargyline caused an appr. 50% decrease of DOPAC content of most of the nuclei in 10 min; the effectivity of the drug did not show parallelism with that of haloperidol. The monoamine oxidase inhibition caused no change in the DOPAC level in the hypothalamic periventricular and paraventricular nuclei. Results are discussed as a consequence of different reactivity of various DA-ergic terminals and catecholamine cell bodies to haloperidol and pargyline.
采用新开发的放射酶法同时测定大鼠脑纹状体、边缘系统、下丘脑以及含儿茶酚胺的细胞群中的去甲肾上腺素（NA）、多巴胺（DA）和二羟基苯乙酸（DOPAC）。在各个脑区中，仅能确定DOPAC与DA含量之间存在松散的关系。在正中隆起中发现相对DOPAC水平（DOPAC/DA比值）最低，而下丘脑室旁核中该比值最高。氟哌啶醇仅使部分被检测核团（纹状体、嗅结节、杏仁中央核）中的DOPAC水平升高，而在其他边缘区域以及下丘脑背内侧核、弓状核和室旁核中，氟哌啶醇被证明无效。氟哌啶醇可使蓝斑核中的DOPAC水平降低。帕吉林在10分钟内使大多数核团的DOPAC含量降低约50%；该药物的有效性与氟哌啶醇不呈平行关系。单胺氧化酶抑制作用并未使下丘脑室旁核和室旁核中的DOPAC水平发生变化。作为各种多巴胺能终末和儿茶酚胺细胞体对氟哌啶醇和帕吉林反应性不同的结果，对这些结果进行了讨论。
