Falko J M, Williams J C, Harvey D G, Weidman S W, Schonfeld G, Dodson W E
J Pediatr. 1979 Oct;95(4):523-9. doi: 10.1016/s0022-3476(79)80755-6.
Two patients with systemic lupus erythematosus, including one with neuropathologic findings, had recurrent multifocal neurologic dysfunction and hyperlipoproteinemia. The lipoprotein disturbances were complex and variable over time. Deficient lipoprotein lipase was found in both patients and appeared to be related temporally to neurologic deterioration. One of these patients had neurologic disease and lipoprotein abnormalities 2 1/2 years before SLE could be documented serologically. These studies suggest that lipoprotein lipase deficiency may be a marker for the endothelial disorder causing cerebral vasculopathy in SLE.
两名系统性红斑狼疮患者，其中一名有神经病理学发现，出现了复发性多灶性神经功能障碍和高脂蛋白血症。脂蛋白紊乱情况复杂且随时间变化。两名患者均发现脂蛋白脂肪酶缺乏，且在时间上似乎与神经功能恶化有关。其中一名患者在血清学确诊系统性红斑狼疮的2年半之前就出现了神经疾病和脂蛋白异常。这些研究表明，脂蛋白脂肪酶缺乏可能是系统性红斑狼疮中导致脑血管病的内皮功能障碍的一个标志。
