Ursing B, Kamme C
Lancet. 1975 Apr 5;1(7910):775-7. doi: 10.1016/s0140-6736(75)92438-1.
Five patients with Crohn's disease for 4 months to 12 years were treated with metronidazole. Four of them improved after 2-4 weeks' treatment. In three of them corticosteroids and sulphasalazine could be withdrawn. One patient did not improve until 4 months of metronidazole treatment had passed and corticosteroids were reintroduced. In three patients metronidazole was discontinued after 4-6 months of treatment. Two of them had no signs or symptoms of relapse 3 and 6 months later. The third patient is free from symptoms but laboratory data indicate disease activity.
五名患有克罗恩病4个月至12年的患者接受了甲硝唑治疗。其中四名患者在治疗2至4周后病情有所改善。他们中的三名患者可以停用皮质类固醇和柳氮磺胺吡啶。一名患者在接受甲硝唑治疗4个月后病情才有所改善，随后重新使用了皮质类固醇。三名患者在治疗4至6个月后停用了甲硝唑。其中两名患者在3个月和6个月后没有复发的迹象或症状。第三名患者没有症状，但实验室数据表明疾病仍处于活动期。
