De Vries J E, Rümke P
Br J Cancer Suppl. 1973 Aug;1:97-102.
Using the lymphocyte microcytotoxicity test on melanoma cultures, 62 out of 112 patients appeared to have cytotoxic lymphocytes. Although not systematically tested, cross-reactivity of cytotoxic lymphocytes on glioma and hypernephroma cultures was found in a few instances. Some healthy individuals who regularly provided the control lymphocytes occasionally showed lymphocyte cytotoxicity, which implies that probably only regular positive findings are of any significance in patients. Although BCG scarifications had been shown in earlier clinical experiments to cause some regression of the tumour volume of pulmonary metastases of short duration in a few patients, no significant “favourable” changes were noticed in the laboratory findings in 10 patients treated by 8 weekly BCG scarifications.
在黑色素瘤培养物上进行淋巴细胞微细胞毒性试验，112例患者中有62例似乎具有细胞毒性淋巴细胞。虽然未进行系统检测，但在少数情况下发现细胞毒性淋巴细胞对神经胶质瘤和肾上腺肿瘤培养物有交叉反应。一些定期提供对照淋巴细胞的健康个体偶尔也表现出淋巴细胞细胞毒性，这意味着可能只有在患者中经常出现的阳性结果才有意义。尽管在早期临床实验中已表明，卡介苗划痕接种在少数患者中可使肺转移瘤体积在短时间内出现一定程度的缩小，但在10例接受每周1次、共8次卡介苗划痕接种治疗的患者中，实验室检查结果未发现明显的“有利”变化。
