Wright R, Eade O E, Chisholm M, Hawksley M, Lloyd B, Moles T M, Edwards J C, GArdner M J
Lancet. 1975 Apr 12;1(7911):817-20. doi: 10.1016/s0140-6736(75)93000-7.
Patients who had received halothane within a periof of one year and who required another anaesthetic were allocated at random to be given halothane or a control anaesthetic, the control being fiben using halothane-free apparatus. There were 76 patients entries in each group. Serum-glutamic-oxaloacetic-transaminase (S.G.O.T.) levels were measured before the anaesthetics and serially postoperatively for two to three weeks. The S.G.O.T. levels in the halothane group were significantly higher than in the controls. High levels were confined to patients who had had less than four previous halothane anaesthetics, increases above normal in the remainder and in the controls being rate. 1 patient in the halothane group had an S.G.O.T. of 440 I.U. per litre and hepatocellular necrosis on liver biopsy. 2 patients in the halothane group whose S.G.O.T.s rose to more than twice normal showed a similar reaction to re-exposure to halothane, although they had not shown a reaction to an intervening control anaesthetic.
在一年之内接受过氟烷麻醉且需要再次进行麻醉的患者被随机分配，分别给予氟烷或对照麻醉剂，对照麻醉剂使用不含氟烷的设备，通过芬苯进行麻醉。每组有76名患者。在麻醉前以及术后连续两到三周测量血清谷氨酸草酰乙酸转氨酶（S.G.O.T.）水平。氟烷组的S.G.O.T.水平显著高于对照组。高水平仅限于之前接受氟烷麻醉次数少于四次的患者，其余患者以及对照组中高于正常水平的情况较少。氟烷组中有1名患者的S.G.O.T.为每升440国际单位，肝脏活检显示有肝细胞坏死。氟烷组中有2名患者的S.G.O.T.升至正常水平两倍以上，尽管他们在中间的对照麻醉中未出现反应，但再次接触氟烷时出现了类似反应。
