阿司匹林抗血栓形成和抗止血作用的酶促机制。
An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin.
作者信息
Willis A L
出版信息
Science. 1974 Jan 25;183(4122):325-7. doi: 10.1126/science.183.4122.325.
PMID:4809076
Abstract
Aspirin-type drugs may inhibit irreversible clumping of human blood platelets by blocking the enzymatic conversion of arachidonic acid to a hitherto undiscovered factor, labile aggregation-stimulating substance, which triggers aggregation and to prostaglandin E(2), which sensitizes the platelets to its aggregatory effects.
摘要
阿司匹林类药物可能通过阻断花生四烯酸向一种迄今未被发现的因子（不稳定的聚集刺激物质，它触发聚集）和前列腺素E(2)（使血小板对其聚集作用敏感）的酶促转化，来抑制人体血小板的不可逆聚集。
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