α-（N）-甲酰基杂芳基硫代半卡巴腙。对肿瘤来源的核糖核苷二磷酸还原酶的抑制作用及其与体内抗肿瘤活性的相关性。 - Suppr

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超能文献

Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity.

作者信息

French F A, Blanz E J, Shaddix S C, Brockman R W

出版信息

J Med Chem. 1974 Feb;17(2):172-81. doi: 10.1021/jm00248a006.

DOI:10.1021/jm00248a006

PMID:4809253

Abstract

摘要

相似文献

Alpha-(N)-formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity.α-（N）-甲酰基杂芳基硫代半卡巴腙。对肿瘤来源的核糖核苷二磷酸还原酶的抑制作用及其与体内抗肿瘤活性的相关性。

J Med Chem. 1974 Feb;17(2):172-81. doi: 10.1021/jm00248a006.

Potential antitumor agents. 6. Possible irreversible inhibitors of ribonucleoside diphosphate reductase.潜在的抗肿瘤药物。6. 核糖核苷二磷酸还原酶的可能不可逆抑制剂。

J Med Chem. 1972 Nov;15(11):1154-8. doi: 10.1021/jm00281a015.

Potential antitumor agents. 10. Synthesis and biochemical properties of 5-N-alkylamino-,N,N-dialkylamino-, and N-alkylacetamido-1-formylisoquinoline thiosemicarbazones.潜在的抗肿瘤剂。10. 5-N-烷基氨基、N,N-二烷基氨基和N-烷基乙酰氨基-1-甲酰基异喹啉硫代半卡巴腙的合成及生化性质

J Med Chem. 1974 Nov;17(11):1145-50. doi: 10.1021/jm00257a004.

Potential antitumor agents. 9. 2-Formyl(m-amino)phenylpyridine thiosemicarbazones.潜在的抗肿瘤剂。9. 2-甲酰基（间氨基）苯基吡啶硫代半卡巴腙

J Med Chem. 1974 Jun;17(6):631-5. doi: 10.1021/jm00252a012.

Alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazone inhibitors of ribonucleoside diphosphate reductase.核糖核苷二磷酸还原酶的α-（N）-杂环羧醛缩氨基硫脲抑制剂

Cancer Res. 1974 Jun;34(6):1308-14.

4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, a second-generation antineoplastic agent of the alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazone series.4-甲基-5-氨基-1-甲酰基异喹啉硫代半卡巴腙，α-(N)-杂环羧醛硫代半卡巴腙系列的第二代抗肿瘤剂。

Cancer Res. 1977 Jun;37(6):1692-6.

Potential antitumor agents. 11. Inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurines.潜在的抗肿瘤药物。11. 碱性磷酸酶抑制剂，一种与肿瘤细胞对6-硫代嘌呤耐药性有关的酶。

J Med Chem. 1974 Sep;17(9):934-8. doi: 10.1021/jm00255a005.

Potential antitumor agents. IV. 4-substituted 1-formylisoquinoline thiosemicarbazones.潜在的抗肿瘤药物。IV. 4-取代的1-甲酰基异喹啉硫代半卡巴腙

J Med Chem. 1970 May;13(3):431-4. doi: 10.1021/jm00297a023.

Kethoxal bis(thiosemicarbazone). I. Effects against experimental tumors.乙二醛双（硫代半卡巴腙）。I. 对实验性肿瘤的作用。

Cancer Res. 1965 Oct;25(9):1410-6.

Potential antitumor agents. 7. 4'-Diethyleneoxy derivatives of -(N)-heterocyclic carboxaldehyde thiosemicarbazones.潜在的抗肿瘤剂。7. -(N)-杂环羧醛缩氨基硫脲的4'-二乙氧基衍生物。

J Med Chem. 1973 Jun;16(6):715-7. doi: 10.1021/jm00264a035.

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Desulfurization of thiosemicarbazones: the role of metal ions and biological implications.硫代卡巴肼的脱硫作用：金属离子的作用及生物学意义。

J Biol Inorg Chem. 2024 Feb;29(1):3-31. doi: 10.1007/s00775-023-02037-7. Epub 2023 Dec 26.

Synthesis of some novel 2-(3-cyano -6-(thiophen- 2-yl)-4,4'- bipyridin-2- yloxy)acetohydrazide derivatives: assessment of their cytotoxic activity.一些新型2-(3-氰基-6-(噻吩-2-基)-4,4'-联吡啶-2-基氧基)乙酰肼衍生物的合成：其细胞毒性活性评估

BMC Chem. 2020 Jun 2;14(1):40. doi: 10.1186/s13065-020-00692-4. eCollection 2020 Dec.

Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds.苯甲酰基缩硫代氨基脲类似物的异喹啉及相关化合物的合成、细胞毒性和抗疟活性。

Molecules. 2010 Feb 23;15(2):988-96. doi: 10.3390/molecules15020988.

Synthesis and structure-activity correlation studies of metal complexes of alpha-N-heterocyclic carboxaldehyde thiosemicarbazones in Shewanella oneidensis.嗜铁钩端螺旋菌中α-N-杂环羧醛缩氨基硫脲金属配合物的合成及构效关系研究

Int J Environ Res Public Health. 2005 Apr;2(1):170-4. doi: 10.3390/ijerph2005010170.

Inhibitors of ribonucleotide reductase alter DNA repair in human fibroblasts through specific depletion of purine deoxynucleotide triphosphates.核糖核苷酸还原酶抑制剂通过特异性消耗嘌呤脱氧三磷酸核苷酸来改变人类成纤维细胞中的DNA修复。

Cell Biol Toxicol. 1984 Oct;1(1):81-94. doi: 10.1007/BF00125567.

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