Estapé J, Millá A, Prats M, Herranz M, Visa J
Med Clin (Barc). 1979 Aug 15;73(4):136-9.
A group of 32 patients with disseminated breast cancer were submitted to polychemotherapy following Cooper's protocol. Vincristine, cyclophosphamide, 5-fluorouracil, and prednisone were administered. The fifth drug used by Cooper, methotrexate, was not included in the therapy program because of difficulties in obtaining it. Both the objective and subjective results were similar to those of other authors using similar drug associations, while toxicity was moderate. Although this treatment is effective to some degree, the authors feel that further research should be carried out on more potent drugs, or in different combinations, in order to get a more definite chemotherapeutic effect in patients with breast cancer.
一组32例弥漫性乳腺癌患者按照库珀方案接受了多药化疗。使用了长春新碱、环磷酰胺、5-氟尿嘧啶和泼尼松。库珀使用的第五种药物甲氨蝶呤因获取困难未纳入治疗方案。客观和主观结果与其他使用类似药物组合的作者的结果相似，而毒性为中度。尽管这种治疗在一定程度上有效，但作者认为应该对更有效的药物或不同的组合进行进一步研究，以便在乳腺癌患者中获得更明确的化疗效果。
