Taddeini L, Frantz I, Sanghvi A
J Lipid Res. 1974 Jan;15(1):84-8.
Hepatic sterol synthesis is accelerated in animals after a single dose of allylisopropylacetamide, a chemical known to be porphyrogenic. Evidence is provided to show that enhanced sterol biosynthesis is due to an increased formation of mevalonic acid, indicating that the primary site of action of the chemical is on one or more steps in the pathway from acetate to mevalonate.
单次给予烯丙基异丙基乙酰胺(一种已知可致卟啉生成的化学物质)后,动物肝脏中的固醇合成会加速。有证据表明,固醇生物合成的增强是由于甲羟戊酸的生成增加,这表明该化学物质的主要作用位点是在从乙酸盐到甲羟戊酸的途径中的一个或多个步骤上。