Koestner A, Swenberg J A, Denlinger R H
Natl Cancer Inst Monogr. 1979 May(51):211-7.
Host factors are operative in transplacental carcinogenesis. There are species, strain, sex, and individual differences in susceptibility to carcinogens. Rat fetuses are over 50 times more susceptible than adults to the oncogenic effects of ENU, yet are less susceptible to tumor induction with DMN. Immune mechanisms do not seem to affect the latency period, incidence, location, and type of neurogenic neoplasms, although tumor-specific antigens are demonstrable in neoplastic neuroectodermal cells. Although placental barriers, DNA repair capacities, age at exposure, hormonal interaction, and immune responsiveness may be singled out as possible causes for species, strain, sex, and individual variations in susceptibility to the neuro-oncogenic potential of ENU, no definitive proof of the mechanism of action of any of these factors has yet been presented.
宿主因素在经胎盘致癌过程中起作用。在对致癌物的易感性方面存在物种、品系、性别和个体差异。大鼠胎儿对ENU致癌作用的易感性比成年大鼠高50倍以上，但对DMN诱导肿瘤的易感性较低。免疫机制似乎不影响神经源性肿瘤的潜伏期、发病率、位置和类型，尽管在肿瘤性神经外胚层细胞中可证实肿瘤特异性抗原。虽然胎盘屏障、DNA修复能力、接触时的年龄、激素相互作用和免疫反应性可能被认为是ENU神经致癌潜能的物种、品系、性别和个体易感性差异的可能原因，但尚未提供任何这些因素作用机制的确切证据。
