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γ-氨基丁酸（GABA）与多胺之间的调节相互关系。I. 脑内GABA水平与多胺代谢

Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism.

作者信息

Seiler N, Bink G, Grove J

出版信息

Neurochem Res. 1979 Aug;4(4):425-35. doi: 10.1007/BF00964637.

DOI:10.1007/BF00964637
PMID:481678
Abstract

Elevation of brain GABA levels by GABA-T inhibition is accompanied by a decrease of S-adenosylmethionine decarboxylase activity. This is followed by an increase of ornithine decarboxylase activity and a severalfold increase of brain putrescine levels. Spermidine and spermine levels are not significantly affected under these conditions. These unexpected findings support a regulatory interaction between GABA and polyamine metabolism.

摘要

通过抑制γ-氨基丁酸转氨酶（GABA-T）来提高脑内γ-氨基丁酸（GABA）水平，会伴随S-腺苷甲硫氨酸脱羧酶活性降低。随后鸟氨酸脱羧酶活性增加，脑内腐胺水平增加数倍。在这些条件下，亚精胺和精胺水平未受到显著影响。这些意外发现支持了GABA与多胺代谢之间的调节相互作用。

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Regulatory interrelations between GABA and polyamines. I. Brain GABA levels and polyamine metabolism.γ-氨基丁酸（GABA）与多胺之间的调节相互关系。I. 脑内GABA水平与多胺代谢
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本文引用的文献

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PURIFICATION AND PROPERTIES OF RAT LIVER ORNITHINE DELTA-TRANSAMINASE.大鼠肝脏鸟氨酸δ-转氨酶的纯化及性质
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5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase.5-氟甲基鸟氨酸，一种L-鸟氨酸：2-氧代酸氨基转移酶的不可逆特异性抑制剂。
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Regulatory interrelations between GABA and polyamines. II. Effect of GABA on ornithine decarboxylase and putrescine levels in cell culture.
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[Transformation of glutamic acid, putrescine and ornithine into gamma-aminobutyric acid in brain].[脑内谷氨酸、腐胺和鸟氨酸向γ-氨基丁酸的转化]
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Ornithine decarboxylase activity in developing rat brain.发育中大鼠大脑中的鸟氨酸脱羧酶活性
J Neurochem. 1972 Jun;19(6):1471-81. doi: 10.1111/j.1471-4159.1972.tb05090.x.
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On the role of S-adenosyl-L-methionine in the biosynthesis of spermidine by rat prostate.S-腺苷-L-甲硫氨酸在大鼠前列腺生物合成亚精胺中的作用
J Biol Chem. 1969 Feb 25;244(4):682-93.
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Acetyl-CoA: 1,4-diaminobutane N-acetyltransferase. Occurrence in vertebrate organs and subcellular localization.乙酰辅酶A：1,4 - 二氨基丁烷N - 乙酰转移酶。在脊椎动物器官中的分布及亚细胞定位。
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Effects of methylglyoxal-bis(guanylhydrazone) on polyamine metabolism in spleens of mice with disseminated L1210 lymphoid leukemia.甲基乙二醛双（脒腙）对患有播散性L1210淋巴细胞白血病小鼠脾脏中多胺代谢的影响。
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