Godard C, Geering J M, Geering K, Vallotton M B
Pediatr Res. 1979 Jun;13(6):742-5. doi: 10.1203/00006450-197906000-00004.
Plasma renin activity was determined in 25 healthy, full-term, newborn infants aged 1 day to 9 weeks. High values were found, the mean level at 1-2 days of life (24.8 +/- 8.4 ng/ml/hr, SE) being significantly higher than the mean levels at 7-9 days (5.8 +/- 1.5) and at 4-9 weeks (8.1 +/- 1.3) (P less than 0.05). No correlation was found between plasma renin activity and systolic blood pressure, hematocrit, creatinine clearance, serum sodium, or serum potassium. Plasma renin activity (log values) was inversely correlated with sodium intake (r = -0.58) or with urinary sodium (r = -0.44), and positively with urinary osmolality (r = 0.67). The correlations reached higher coefficients if only infants aged less than or equal to 9 days were considered. In addition, vasopressin was measured by radioimmunoassay in the urine. The daily excretion was lower in newborn infants (9.4 +/- 1.6 ng/m2/day, SE, at 1-2 days of postnatal life) than in healthy children (37.1 +/- 5.6), and was significantly correlated with creatinine clearance (r = 0.69), but not with urinary osmolality.
对25名年龄在1天至9周的健康足月新生儿测定了血浆肾素活性。结果发现活性值较高，出生后1 - 2天的平均水平（24.8 +/- 8.4 ng/ml/hr，标准误）显著高于7 - 9天（5.8 +/- 1.5）和4 - 9周（8.1 +/- 1.3）时的平均水平（P小于0.05）。未发现血浆肾素活性与收缩压、血细胞比容、肌酐清除率、血清钠或血清钾之间存在相关性。血浆肾素活性（对数数值）与钠摄入量（r = -0.58）或尿钠（r = -0.44）呈负相关，与尿渗透压呈正相关（r = 0.67）。如果仅考虑年龄小于或等于9天的婴儿，相关性系数更高。此外，通过放射免疫分析法测定了尿液中的血管加压素。新生儿的每日排泄量（出生后1 - 2天为9.4 +/- 1.6 ng/m2/天，标准误）低于健康儿童（37.1 +/- 5.6），且与肌酐清除率显著相关（r = 0.69），但与尿渗透压无关。
