妥拉唑啉的肺血管舒张作用。

Pulmonary vasodilator action of tolazoline.

作者信息

Goetzman B W, Milstein J M

出版信息

Pediatr Res. 1979 Aug;13(8):942-4. doi: 10.1203/00006450-197908000-00014.

DOI:10.1203/00006450-197908000-00014

PMID:481968

Abstract

The pulmonary vasodilator action of tolazoline in newborn lambs was shown to be mediated via histamine receptors. Maximal changes in pulmonary vascular resistance, deltaPVR, were calculated as percents of the base line value, %deltaPVR. The mean %deltaPVR after tolazoline, 1 mg/kg, was -25 +/- 4% for eight lambs. Four lambs then received the histamine H1 receptor antagonist, diphenhydramine, and the mean %deltaPVR due to tolazoline was -12 +/- 4%. Four lambs received the H2 receptor antagonist, metiamide, and the mean %delta PVR due to tolazoline was -18 +/- 5%. After both H1 and H2 antagonists, the mean %deltaPVR due to tolazoline was +6 +/- 8%. Therefore, both histamine H1 and H2 receptors were involved in the vasodilator response to tolazoline.

摘要

已证明妥拉唑啉在新生羔羊中的肺血管舒张作用是通过组胺受体介导的。肺血管阻力的最大变化量，即△PVR，以基线值的百分比计算，即%△PVR。对于8只羔羊，给予1mg/kg妥拉唑啉后的平均%△PVR为-25±4%。然后，4只羔羊接受组胺H1受体拮抗剂苯海拉明，妥拉唑啉所致的平均%△PVR为-12±4%。另外4只羔羊接受H2受体拮抗剂甲硫米特，妥拉唑啉所致的平均%△PVR为-18±5%。在同时给予H1和H2拮抗剂后，妥拉唑啉所致的平均%△PVR为+6±8%。因此，组胺H1和H2受体均参与了对妥拉唑啉的血管舒张反应。