Kirkham T H, Kamin D F
J Neurol Neurosurg Psychiatry. 1974 Feb;37(2):191-4. doi: 10.1136/jnnp.37.2.191.
This is the first reported case of Wilson's disease where a global defect of saccadic eye movements has been documented by electro-oculography. The defect of rapid eye movements is discussed in relation to current anatomical, pathological, and experimental work relating to the descending frontobulbar saccadic eye movement system. It is suggested that the caudate nucleus pathology in Wilson's disease might be responsible for the defect of saccadic movement by interrupting a descending polysynaptic pathway.
这是首例经眼电图记录证实存在眼球扫视运动全面缺陷的威尔逊病病例。结合当前与额桥束眼球扫视运动下行系统相关的解剖学、病理学及实验研究,对快速眼球运动缺陷进行了讨论。研究表明,威尔逊病中的尾状核病变可能通过中断下行多突触通路导致扫视运动缺陷。