辛德毕斯病毒形态发生过程中病毒包膜前体的切割
Cleavage of a viral envelope precursor during the morphogenesis of Sindbis virus.
作者信息
Jones K J, Waite M R, Bose H R
出版信息
J Virol. 1974 Apr;13(4):809-17. doi: 10.1128/JVI.13.4.809-817.1974.
Abstract
In cells infected with a temperature-sensitive mutant of Sindbis virus, the cleavage of the precursor to one of the viral envelope proteins does not occur at the nonpermissive temperature. This precursor is found associated with the plasma membrane fraction obtained from the infected cell. Since this is the site at which the virus matures, this finding suggests that during Sindbis virus replication the precursor to the smaller proteins associates with the cell membrane and is then cleaved during the maturation of the virus.
摘要
在感染了辛德毕斯病毒温度敏感突变体的细胞中，病毒包膜蛋白之一的前体在非允许温度下不会发生切割。这种前体与从感染细胞中获得的质膜部分相关联。由于这是病毒成熟的部位，这一发现表明，在辛德毕斯病毒复制过程中，较小蛋白质的前体与细胞膜结合，然后在病毒成熟过程中被切割。
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