Shulman A G
West J Med. 1974 Apr;120(4):278-81.
In the past century diverticular disease of the colon has changed from being almost unknown to becoming the most common disease of the colon. Studies in Britain indicated that the pathological basis of the disease is a thickening of the colonic musculature, with diverticulosis and diverticulitis developing because of increased intracolonic pressures generated by the thickened colon wall. This pressure can be sharply reduced by increased colonic bulk. Geographical and anthropological data reveal that diverticular disease results from Western civilization's food habits, specifically the reduced fiber content in food. There is evidence that increasing the dietary intake of fiber by the addition of bran can prevent formation of diverticula and relieve the symptoms of established disease. Large scale studies are recommended both as treatment and to further test the validity of this concept.
在过去的一个世纪里,结肠憩室病已从几乎无人知晓发展成为结肠最常见的疾病。英国的研究表明,该病的病理基础是结肠肌肉组织增厚,憩室病和憩室炎的发生是由于增厚的结肠壁产生的结肠内压力增加所致。通过增加结肠容量可大幅降低这种压力。地理和人类学数据显示,憩室病是西方文明饮食习惯的结果,特别是食物中纤维含量的减少。有证据表明,通过添加麸皮增加膳食纤维的摄入量可以预防憩室的形成,并缓解已患疾病的症状。建议进行大规模研究,既作为治疗手段,也为了进一步检验这一概念的有效性。