啮齿动物肝脏和大脑中鸟嘌呤脱氨酶及其抑制剂的诱导作用。
Induction of guanine deaminase and its inhibitor in rodent liver and brain.
作者信息
Sitaramayya A, Ali S, Kumar K S, Krishnan P S
出版信息
Biochem J. 1974 Feb;138(2):143-6. doi: 10.1042/bj1380143.
Abstract
- Guanine deaminase activities in homogenates and supernatant fractions of liver and brain of rat and mouse were elevated by administration of guanine to the animals. The maximum induction in mouse tissues occurred within 24h and in rat tissues within 48h. 2. Mitochondria of rat (but not mouse) liver and brain contain an inhibitor of supernatant guanine deaminase, and this was also increased by guanine treatment. 3. Administration of ethionine, cycloheximide or actinomycin D prevented the guanine-dependent increase in deaminase activity and also the increase in mitochondrial inhibitory activity; chloramphenicol suppressed only the latter.
摘要
- 给大鼠和小鼠施用鸟嘌呤后，其肝脏和大脑匀浆及上清液部分中的鸟嘌呤脱氨酶活性升高。小鼠组织中的最大诱导在24小时内出现，大鼠组织中的最大诱导在48小时内出现。2. 大鼠（而非小鼠）肝脏和大脑的线粒体含有上清液鸟嘌呤脱氨酶的抑制剂，鸟嘌呤处理也会使其增加。3. 施用乙硫氨酸、环己酰亚胺或放线菌素D可阻止鸟嘌呤依赖性的脱氨酶活性增加以及线粒体抑制活性的增加；氯霉素仅抑制后者。
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本文引用的文献
1
Studies on guanine deaminase and its inhibitors in rat tissue.大鼠组织中的鸟嘌呤脱氨酶及其抑制剂研究。
Biochem J. 1967 Mar;102(3):691-704. doi: 10.1042/bj1020691.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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Potent xanthine oxidase inhibitors--4(or 5)-diazoimidazole-5(or 4)-carboxamide and two related compounds.强效黄嘌呤氧化酶抑制剂——4（或5）-重氮咪唑-5（或4）-甲酰胺及两种相关化合物。
Biochem Pharmacol. 1969 Apr;18(4):955-7. doi: 10.1016/0006-2952(69)90076-8.
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Differential induction of cytoplasmic guanine deaminase isozymes under guanine stress in rat liver and brain.鸟嘌呤应激下大鼠肝脏和大脑中细胞质鸟嘌呤脱氨酶同工酶的差异诱导
Biochem Biophys Res Commun. 1970 Sep 10;40(5):1002-7. doi: 10.1016/0006-291x(70)90892-2.
5
Modulation of guanine deaminase.鸟嘌呤脱氨酶的调节
Biochem J. 1973 Apr;131(4):683-7. doi: 10.1042/bj1310683.
6
Guanine deaminase in rat liver and mouse liver and brain.大鼠肝脏、小鼠肝脏和大脑中的鸟嘌呤脱氨酶。
Biochem J. 1972 Aug;128(5):1079-88. doi: 10.1042/bj1281079.
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