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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Sitaramayya A, Ali S, Kumar K S, Krishnan P S

Biochem J. 1974 Feb;138(2):143-6. doi: 10.1042/bj1380143.

Guanine deaminase activities in homogenates and supernatant fractions of liver and brain of rat and mouse were elevated by administration of guanine to the animals. The maximum induction in mouse tissues occurred within 24h and in rat tissues within 48h. 2. Mitochondria of rat (but not mouse) liver and brain contain an inhibitor of supernatant guanine deaminase, and this was also increased by guanine treatment. 3. Administration of ethionine, cycloheximide or actinomycin D prevented the guanine-dependent increase in deaminase activity and also the increase in mitochondrial inhibitory activity; chloramphenicol suppressed only the latter.

给大鼠和小鼠施用鸟嘌呤后，其肝脏和大脑匀浆及上清液部分中的鸟嘌呤脱氨酶活性升高。小鼠组织中的最大诱导在24小时内出现，大鼠组织中的最大诱导在48小时内出现。2. 大鼠（而非小鼠）肝脏和大脑的线粒体含有上清液鸟嘌呤脱氨酶的抑制剂，鸟嘌呤处理也会使其增加。3. 施用乙硫氨酸、环己酰亚胺或放线菌素D可阻止鸟嘌呤依赖性的脱氨酶活性增加以及线粒体抑制活性的增加；氯霉素仅抑制后者。

Sitaramayya A, Ali S, Kumar K S, Krishnan P S

Biochem J. 1974 Feb;138(2):143-6. doi: 10.1042/bj1380143.

Guanine deaminase activities in homogenates and supernatant fractions of liver and brain of rat and mouse were elevated by administration of guanine to the animals. The maximum induction in mouse tissues occurred within 24h and in rat tissues within 48h. 2. Mitochondria of rat (but not mouse) liver and brain contain an inhibitor of supernatant guanine deaminase, and this was also increased by guanine treatment. 3. Administration of ethionine, cycloheximide or actinomycin D prevented the guanine-dependent increase in deaminase activity and also the increase in mitochondrial inhibitory activity; chloramphenicol suppressed only the latter.

给大鼠和小鼠施用鸟嘌呤后，其肝脏和大脑匀浆及上清液部分中的鸟嘌呤脱氨酶活性升高。小鼠组织中的最大诱导在24小时内出现，大鼠组织中的最大诱导在48小时内出现。2. 大鼠（而非小鼠）肝脏和大脑的线粒体含有上清液鸟嘌呤脱氨酶的抑制剂，鸟嘌呤处理也会使其增加。3. 施用乙硫氨酸、环己酰亚胺或放线菌素D可阻止鸟嘌呤依赖性的脱氨酶活性增加以及线粒体抑制活性的增加；氯霉素仅抑制后者。