Kawasaki H, Watanabe S, Ueki S
Pharmacol Biochem Behav. 1979 Jun;10(6):907-15. doi: 10.1016/0091-3057(79)90066-2.
Electrical stimulation of the posterior hypothalamus (PH) and the mesencephalic reticular formation (MRF) in unanesthetized, unrestrained rats with chronic electrode implants and an arterial cannula elicited a rise in blood pressure accompanied by behavioral changes such as exploration, flight or escape responses. Pentobarbital inhibited both the pressor and behavioral responses to PH and MRF stimulation. Chlorpormazine, diazepam and imipramine depressed the pressor response to PH stimulation rather than that to MRF stimulation with affecting the behavioral responses. It is concluded from these results that chlorpromazine, diazepam and imipramine exert their action on the neural pathway involved in the pressor response rather than on that inducing behavioral responses, whereas pentobarbital affects more extended brain areas related to these neural systems.
对植入慢性电极和动脉插管的未麻醉、未束缚大鼠的下丘脑后部（PH）和中脑网状结构（MRF）进行电刺激，会引起血压升高，并伴有探索、逃跑或逃避反应等行为变化。戊巴比妥抑制对PH和MRF刺激的升压和行为反应。氯丙嗪、地西泮和丙咪嗪抑制对PH刺激的升压反应，而非对MRF刺激的升压反应，同时影响行为反应。从这些结果得出结论，氯丙嗪、地西泮和丙咪嗪对参与升压反应的神经通路起作用，而非对诱发行为反应的神经通路起作用，而戊巴比妥影响与这些神经系统相关的更广泛脑区。
