血液透析装置各部件与人体血液的实验性相互作用。

Experimental interactions of components of hemodialysis units with human blood.

作者信息

Zucker W H, Shinoda B A, Mason R G

出版信息

Am J Pathol. 1974 Apr;75(1):139-60.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1910818/

Abstract

An in vitro model test system for estimation of the blood compatibility of hemodialysis membranes and tubing is described. The model test system consists of a modified hemodialysis unit and blood pump through which fresh citrated human blood is circulated. The effects of the use of different pump and tubing types upon hematologic and blood coagulation parameters are described. Preexposure of test surfaces to albumin appeared to enhance blood compatibility characteristics of the model test system, whereas preexposure to a high density lipoprotein preparation or a proteinpolysaccharide preparation was without appreciable benefit. Use of blood from subjects receiving aspirin resulted in enhanced blood compatibility in the test system as did use of heparin. Use of Warfarin or dextran did not appear to enhance blood compatibility of test surfaces under the conditions of this test system. Dialysis membranes and tubing which formed parts of the test system were examined by scanning and transmission electron microscopy in control tests and in tests for effects of proteins and antithrombotic agents.

摘要

描述了一种用于评估血液透析膜和管路血液相容性的体外模型测试系统。该模型测试系统由一个改良的血液透析单元和血泵组成，新鲜的枸橼酸化人血通过该系统循环。描述了使用不同类型的泵和管路对血液学和血液凝固参数的影响。测试表面预先暴露于白蛋白似乎可增强模型测试系统的血液相容性特征，而预先暴露于高密度脂蛋白制剂或蛋白多糖制剂则没有明显益处。使用接受阿司匹林治疗的受试者的血液以及使用肝素均导致测试系统中的血液相容性增强。在该测试系统的条件下，使用华法林或右旋糖酐似乎并未增强测试表面的血液相容性。在对照测试以及蛋白质和抗血栓剂作用测试中，通过扫描电子显微镜和透射电子显微镜对构成测试系统一部分的透析膜和管路进行了检查。