雌激素对小鼠子宫组织中致癌RNA病毒蛋白的调节作用(38467)

Oncornaviral protein modulation in mouse uterine tissue by estrogen (38467).

作者信息

Fowler A K, Kouttab N M, Kind P D, Strickland J E, Hellman A

出版信息

Proc Soc Exp Biol Med. 1975 Jan;148(1):14-8. doi: 10.3181/00379727-148-38467.

Abstract

Treatment of ovariectomized NIH Swiss mice with estrogens elevated the level of the murine leukemia virus group specific protein and the activity of an RNA-directed DNA polymerase in the uterus. The extent that these markers were raised was dependent on the relative biological potency of the estrogen and on the time interval following treatment. Increases in the levels of both viral marker proteins were evident within 24 hr of treatment and were highest at 48 hr. Subsequently, viral protein levels declined to pretreatment levels.

摘要

用雌激素治疗去卵巢的NIH瑞士小鼠，可提高子宫中鼠白血病病毒群特异性蛋白的水平以及一种RNA指导的DNA聚合酶的活性。这些标志物升高的程度取决于雌激素的相对生物学效价以及治疗后的时间间隔。在治疗后24小时内，两种病毒标志物蛋白的水平均明显升高，并在48小时时达到最高。随后，病毒蛋白水平降至预处理水平。