Hasleton P S, Leonard J C
Q J Med. 1979 Jan;48(189):63-76.
The aortas from 83 patients with dissecting aneurysm were studied histologically. There were two examples of giant-cell arteritis, one of non-specific arteritis and one of syphilis. Apart from these, no constant feature was found in the cases of dissection when compared with 20 controls. In particular there was no difference in the grades of cystic medial necrosis, medionecrosis and fibrosis. Focal fragmentation of elastica was present in the majority of dissections (63 per cent) but similar abnormalities were seen in most controls (85 per cent). The vasa vasorum showed no special features in dissection. Intimal fibrosis and intimal longitudinal muscle were present in both groups studied. Sixteen cases showed 'old' dissections as manifest by either granulation tissue or fibrosis. The histopathological features of the four cases diagnosed clinically as having Marfan's syndrome did not differ from controls.
对83例夹层动脉瘤患者的主动脉进行了组织学研究。有2例巨细胞动脉炎，1例非特异性动脉炎和1例梅毒。除此之外，与20例对照相比，夹层病例中未发现恒定特征。特别是在囊性中层坏死、中层坏死和纤维化程度方面没有差异。大多数夹层（63%）存在弹性纤维局灶性断裂，但大多数对照（85%）也有类似异常。滋养血管在夹层中无特殊表现。两组均存在内膜纤维化和内膜纵行肌。16例表现为“陈旧性”夹层，表现为肉芽组织或纤维化。临床诊断为马凡综合征的4例患者的组织病理学特征与对照无差异。
