大鼠保留血管的超选择性迷走神经切断术。预防应激性溃疡的一种有用工具。

Superselective vagotomy sparing blood vessels in the rat. A useful tool in stress ulcer prevention.

作者信息

Hanisch E, Schwille P Q, Engelhardt W

出版信息

Res Exp Med (Berl). 1979 Jul 20;175(3):293-9. doi: 10.1007/BF01851286.

Abstract

In male Sprague-Dawley rats a microsurgical technique for highly selective vagotomy (HSV; syn. proximal gastric vagotomy) and for superselective vagotomy (SSV; cutting of proximal vagal fibers but sparing the blood vessels) has been developed. Basal acid secretion in both preparations was appr. 60% lower than in sham-operated controls. Acid response to 2-Deoxy-D-glucose (35 mg/kg/h over 4 h) was negative in HSV and SSV rats, whereas in sham rats acid output rose significantly. HSV, during mild stress (= control conditions), renders rats more susceptible to gastric stress ulcerations, whereas SSV with intact mucosal blood flow protects gastric mucosa almost completely. Although SSV, during severe restraint stress, cannot prevent the stress-induced breakdown of mucosal blood flow, gastric ulcerations are reduced to 40% of HSV and sham-operated control rats. SSV appears an elegant tool in stress ulcer research.

摘要

在雄性Sprague-Dawley大鼠中，已开发出一种用于高选择性迷走神经切断术（HSV；同义词：近端胃迷走神经切断术）和超选择性迷走神经切断术（SSV；切断近端迷走神经纤维但保留血管）的显微外科技术。两种制备方法中的基础胃酸分泌比假手术对照组低约60%。HSV和SSV大鼠对2-脱氧-D-葡萄糖（4小时内35毫克/千克/小时）的酸反应为阴性，而假手术大鼠的酸分泌显著增加。在轻度应激（=对照条件）期间，HSV使大鼠更容易发生胃应激性溃疡，而黏膜血流完整的SSV几乎能完全保护胃黏膜。虽然在严重束缚应激期间，SSV不能防止应激诱导的黏膜血流中断，但胃溃疡的发生率降至HSV和假手术对照组大鼠的40%。SSV似乎是应激性溃疡研究中的一种精妙工具。