Iwarson S, Lindberg J, Lundin P
Scand J Gastroenterol. 1979;14(4):497-502.
Adverse liver reactions associated with nitrofurantoin treatment are rare but important complications. Both acute and chronic liver damage have been described. The present report describes five patients who developed chronic liver disease after 1 to 3 years of continued nitrofurantoin treatment. Liver histology was consistent with chronic active hepatitis in four patients, while postnecrotic cirrhosis was observed in one case. Follow-up examinations 2 to 3 years after withdrawal of the drug showed marked improvement clinically and in most cases also histologically.
与呋喃妥因治疗相关的肝脏不良反应虽罕见但却是重要的并发症。急性和慢性肝损伤均有报道。本报告描述了5例在持续使用呋喃妥因治疗1至3年后发生慢性肝病的患者。4例患者的肝脏组织学表现符合慢性活动性肝炎，1例观察到坏死后肝硬化。停药2至3年后的随访检查显示临床症状有显著改善，大多数病例的组织学表现也有改善。
