Harik S I, LaManna J C, Light A I, Rosenthal M
Science. 1979 Oct 5;206(4414):69-71. doi: 10.1126/science.482927.
Unilateral lesion of the locus coeruleus and the resultant norepinephrine depletion in the ipsilateral cerebrum alters the relationship between cerebral metabolic demands and local delivery of oxygen and substrates. This effect of norepinephrine depletion is demonstrated by slower recovery of the redox ratio of cytochrome a,a3 during increased metabolic demands induced by local cortical stimulation.
蓝斑的单侧损伤以及同侧大脑中去甲肾上腺素的耗竭改变了大脑代谢需求与局部氧气和底物供应之间的关系。去甲肾上腺素耗竭的这种效应通过在局部皮层刺激诱导的代谢需求增加期间细胞色素a,a3氧化还原比的恢复较慢得以证明。
