Gordon W E, Hermann H W, Hunter D C
South Med J. 1979 Oct;72(10):1252-3, 1258. doi: 10.1097/00007611-197910000-00011.
Fifty-four postmenopausal patients with atrophic vaginitis satisfactorily completed one to two months' therapy with daily intravaginal application of 0.2 mg of 17 beta-estradiol in a cream base. No significant alterations were noted in the hematologic biochemical, and urine analyses. A number of response criteria showed significant improvement (P less than .01), including the severity rating for atrophic vaginitis, the maturation index of vaginal cells, the frequency and severity of hot flashes, the presence of vaginal dryness and itching, dyspareunia, skin flushing, and the severity of sweating episodes. The incidence of side effects was low and included breast tenderness and abdominal cramping.
54名患有萎缩性阴道炎的绝经后患者采用每日阴道内应用含0.2毫克17β-雌二醇的乳膏基质进行了1至2个月的治疗，治疗效果良好。血液学、生化及尿液分析未发现明显异常。多项反应标准显示有显著改善（P<0.01），包括萎缩性阴道炎的严重程度评分、阴道细胞成熟指数、潮热的频率和严重程度、阴道干燥和瘙痒的情况、性交困难、皮肤潮红以及出汗发作的严重程度。副作用发生率较低，包括乳房压痛和腹部绞痛。
