新生儿叶酸的肾脏丢失
Renal loss of folate in the newborn infant.
作者信息
Landon M J, Hey E N
出版信息
Arch Dis Child. 1974 Apr;49(4):292-6. doi: 10.1136/adc.49.4.292.
Abstract
Renal excretion of folate during the first 5 days of life has been measured in 10 infants of 31 to 40 weeks' gestation and compared with inulin clearance. Average daily folate loss per unit surface area (23 μg/m) was nearly 8 times as high as in adult life and more than enough to account for the observed fall in plasma folate activity. No difference was detected between the pattern of folate excretion in preterm and term infants. Poor tubular reabsorption of filtered folate is thought to be responsible for the loss observed.
摘要
对10名孕龄为31至40周的婴儿出生后头5天的叶酸肾排泄情况进行了测量，并与菊粉清除率进行了比较。每单位表面积的平均每日叶酸损失量（23μg/m）几乎是成人的8倍，足以解释观察到的血浆叶酸活性下降。未检测到早产和足月婴儿叶酸排泄模式之间的差异。滤过叶酸的肾小管重吸收不良被认为是观察到的损失的原因。
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