用短小棒状杆菌处理的小鼠的淋巴细胞和巨噬细胞的体外抗肿瘤作用。
Anti-tumour effect in vitro of lymphocytes and macrophages from mice treated with Corynebacterium parvum.
作者信息
Ghaffar A, Cullen R T, Dunbar N, Woodruff M F
出版信息
Br J Cancer. 1974 Mar;29(3):199-205. doi: 10.1038/bjc.1974.59.
Abstract
Cells from the spleen, lymph node, peripheral blood and peritoneal exudate of mice treated with C. parvum were tested for their ability to inhibit tumour growth in vitro. The peritoneal exudate cells from C. parvum treated mice were extremely effective in inhibiting tumour growth whereas the spleen and peripheral blood cells were only moderately so. In contrast, the lymph node cells caused only a modest inhibition of tumour growth at a very high effector to target cell ratio. Spleen cells from normal mice also exerted a moderate anti-tumour effect.
摘要
对用微小隐孢子虫处理过的小鼠的脾脏、淋巴结、外周血和腹腔渗出液中的细胞进行体外抑制肿瘤生长能力的测试。用微小隐孢子虫处理过的小鼠的腹腔渗出液细胞在抑制肿瘤生长方面极其有效，而脾脏和外周血细胞的效果仅为中等。相比之下，淋巴结细胞在效应细胞与靶细胞比例非常高时，对肿瘤生长的抑制作用仅为适度。正常小鼠的脾细胞也发挥了中等程度的抗肿瘤作用。
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