Brincker H, Wilbek E
Br J Cancer. 1974 Mar;29(3):247-51. doi: 10.1038/bjc.1974.64.
During the period 1962-71 a total of 2544 patients with respiratory sarcoidosis were reported to the Danish Institute of Clinical Epidemiology. Among them 48 patients developed a malignant tumour, the follow-up period ending on 31 December 1971. Only 33·8 cases of cancer were expected if sarcoidosis patients had had the same rates as the general population; the difference between the expected and observed number is statistically significant (0·02 > P > 0·01). Malignant lymphomata occurred 11 times and lung cancer 3 times more frequently than expected. For all other forms of cancer taken together, there was no significant difference between the expected and the observed number of cases.The increased cancer incidence may result from immunological deficiencies in patients with sarcoidosis.
1962年至1971年期间，丹麦临床流行病学研究所共收到2544例呼吸性结节病患者的报告。其中48例患者发生了恶性肿瘤，随访期截至1971年12月31日。如果结节病患者的癌症发病率与普通人群相同，预计只有33.8例癌症；预期病例数与观察到的病例数之间的差异具有统计学意义（0.02 > P > 0.01）。恶性淋巴瘤的发生频率比预期高11倍，肺癌比预期高3倍。对于所有其他形式的癌症，预期病例数与观察到的病例数之间没有显著差异。癌症发病率的增加可能是由于结节病患者的免疫缺陷所致。
