Bademosi O, Osuntokun B O
Trop Geogr Med. 1979 Mar;31(1):53-6.
The results of a steroid on 52 Nigerians (27 males, 25 females, aged 10 to 59 years) with bacteriologically proven pneumococcal meningitis are presented. Twenty-four of the patients were treated with steroids in addition to a standard regime. The clinical features on admission in the two groups were comparable and management other than steroid administration identical. Personality change with impairment of intellect was more frequent and mortality higher in the steroid-treated group although the differences wre not statistically significant. It is concluded that steroids apparently have no beneficial effect and may worsen the prognosis in pneumococcal meningitis.
本文呈现了对52名（27名男性，25名女性，年龄在10至59岁之间）经细菌学证实患有肺炎球菌性脑膜炎的尼日利亚人使用类固醇的结果。其中24名患者除接受标准治疗方案外还接受了类固醇治疗。两组患者入院时的临床特征具有可比性，除类固醇给药外的治疗措施相同。尽管差异无统计学意义，但在接受类固醇治疗的组中，智力受损伴人格改变更为常见，死亡率也更高。得出的结论是，类固醇显然没有有益作用，可能会使肺炎球菌性脑膜炎的预后恶化。
