Mahler D L, Forrest W H
Anesthesiology. 1975 May;42(5):602-7. doi: 10.1097/00000542-197505000-00021.
Because of discrepancies in the estimates of the relative analgesic potencies of hydromorphone and morphine, the drugs were compared in two four-point, double-blind bioassays. In the first study, hydromorphone, 1 and 2 mg, was compared with morphine, 5 and 10 mg, in 31 postoperative patients; in the second, hydromorphone, 0.5 and 1 mg, was compared with morphine, 5 and 10 mg, in 112 postoperative patients. Subjective responses to nurse-observer questions were used to quantitate analgesia for postoperative pain. Hydromorphone is more potent than commonly believed: approximately 0.9 to 1.2 mg is equianalgesic with 10 mg of morphine, with a similar incidence of side effects.
由于氢吗啡酮和吗啡相对镇痛效力的估计存在差异，在两项四点双盲生物测定中对这两种药物进行了比较。在第一项研究中，对31例术后患者使用1毫克和2毫克氢吗啡酮与5毫克和10毫克吗啡进行比较；在第二项研究中，对112例术后患者使用0.5毫克和1毫克氢吗啡酮与5毫克和10毫克吗啡进行比较。通过对护士观察者问题的主观反应来定量术后疼痛的镇痛效果。氢吗啡酮的效力比通常认为的更强：约0.9至1.2毫克氢吗啡酮与10毫克吗啡镇痛效果相当，且副作用发生率相似。
