Phillips S M, Carpenter C B, Lane P
Ann N Y Acad Sci. 1975 Feb 28;249:236-47. doi: 10.1111/j.1749-6632.1975.tb29071.x.
Immunosuppressive bovine alpha globulins of both serum and thymus origin were analyzed for in vitro effects upon the afferent and efferent arcs of the immune system. Although considerable variation in potency occurs between preparations, the functional identity of thymus and serum fractions is apparent. Antigenic recognition and effector capability are not altered whereas the proliferative lymphocyte response is either augmented or suppressed, depending upon the concentration of alpha globulin. A rather selective effect is noted on DNA synthesis and is followed by parallel changes in the development of effector capability, as measured by the development of alloimmune cytotoxic lymphocytes.
对源自血清和胸腺的免疫抑制性牛α球蛋白进行了分析，以研究其对免疫系统传入和传出弧的体外作用。尽管不同制剂之间的效力存在相当大的差异，但胸腺和血清组分的功能特性是明显的。抗原识别和效应能力未改变，而增殖性淋巴细胞反应则根据α球蛋白的浓度增强或受到抑制。观察到对DNA合成有相当选择性的作用，随后在通过同种免疫细胞毒性淋巴细胞的发育来衡量的效应能力发展方面出现平行变化。
