Hayes M J, Morris G K, Hampton J R
Br Med J. 1974 Jul 6;3(5922):10-3. doi: 10.1136/bmj.3.5922.10.
A total of 189 patients with uncomplicated myocardial infarction were selected at random for early or late mobilization and discharge from hospital. Patients were admitted to the study after 48 hours in a coronary care unit if they were free of pain and showed no evidence of heart failure or significant dysrhythmia. Randomization was achieved by monthly cross-over of the three medical wards to which the patients were discharged. One group of patients was mobilized immediately and discharged home after a total of nine days in hospital, and the second group was mobilized on the ninth day and discharged on the 16th day. Out-patient assessment was carried out six weeks after admission. No significant differences were observed between the groups in terms of mortality or morbidity, as reflected by the incidence of recurrent chest pain or myocardial infarction, heart failure, dysrhythmia, or venous thromboembolism detected either clinically or by (125)I-labelled fibrinogen scanning.
总共189例无并发症心肌梗死患者被随机选取以进行早期或晚期活动及出院安排。如果患者在冠心病监护病房48小时后无疼痛且无心力衰竭或明显心律失常的迹象，则纳入研究。通过患者出院前往的三个内科病房每月交叉安排实现随机分组。一组患者立即开始活动，住院九天后出院回家，第二组患者在第九天开始活动并于第16天出院。入院六周后进行门诊评估。两组在死亡率或发病率方面未观察到显著差异，这可通过复发性胸痛或心肌梗死、心力衰竭、心律失常或临床检测到的静脉血栓栓塞的发生率或通过（125）I标记纤维蛋白原扫描反映出来。
