Khmel'nitskiĭ O K, Medvedev Iu A, Morozov M A
Arkh Patol. 1975;37(2):28-34.
A total of 31 biopsy specimens in patients with cancer of the prostate (18 with I and II stages and 13 with III and IV stages of the disease) were investigated. The results obtained were collated with those of the control group (22 observations). Involutional changes in the testes in the patients with cancer of the prostate started earlier and were more pronounced than those in the corresponding age of the control group. The testes in the patients with cancer were characterized by a specific mucoid oedema of the intertubular stroma with outcome into sclerosis. At early stages of the cancer hyperplasia and hypertrophy of Leydig' cells were noted. At final stages of the diseases their number normalized. At the same time the number of Sertoli's cells increased and signs indicating to intensification of their activity appeared.
共对31例前列腺癌患者的活检标本进行了研究（其中18例为Ⅰ期和Ⅱ期，13例为Ⅲ期和Ⅳ期）。将所得结果与对照组（22例观察对象）的结果进行了整理。前列腺癌患者睾丸的退化性变化比对照组相应年龄者开始得更早且更明显。癌症患者的睾丸特征为管间基质出现特定的黏液样水肿并发展为硬化。在癌症早期，可见睾丸间质细胞增生和肥大。在疾病晚期，其数量恢复正常。与此同时，支持细胞数量增加，并出现表明其活性增强的迹象。
