发夹尾：小鼠卵子减数分裂后基因作用的一个案例。
Hairpin-tail: a case of post-reductional gene action in the mouse egg.
作者信息
JOHNSON D R
出版信息
Genetics. 1974 Apr;76(4):795-805. doi: 10.1093/genetics/76.4.795.
Abstract
Hairpin-tail (T(hp)) is a new allele of brachyury on chromosome 17 (linkage group IX) of the mouse. The morphological effects in the heterozygote are on the notochord and the tail. The homozygous abnormal is unknown. T(hp) is unique in that the phenotype of the heterozygote seems to depend on the source of the T(hp) gene. If it is inherited via the egg the phenotype is extreme and death follows in utero. Embryos derived from a T(hp) sperm and a+egg are less abnormal and viable. This is not a simple maternal effect, as T(hp)xT(hp) matings produce two distinct types of heterozygous embryos.
摘要
发夹尾（T(hp)）是小鼠17号染色体（连锁群IX）上短尾基因的一个新等位基因。杂合子的形态学效应体现在脊索和尾巴上。纯合异常情况未知。T(hp)的独特之处在于杂合子的表型似乎取决于T(hp)基因的来源。如果它通过卵子遗传，表型会很极端，胚胎会在子宫内死亡。由T(hp)精子和a+卵子产生的胚胎异常情况较轻且可存活。这不是简单的母体效应，因为T(hp)×T(hp)交配会产生两种不同类型的杂合胚胎。
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