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镰状细胞性状的误区。

The myth of sickle cell trait.

作者信息

Bristow L R

出版信息

West J Med. 1974 Jul;121(1):77-82.

Abstract

Recently emphasis in the problem of sickle hemoglobinopathy has been on mass screening of the black population. Concern about the alleged danger in having sickle cell trait itself is offered as part of the justification. This danger is disputed and a position developed for the benign status of sickle cell trait and the potentially serious social harm to blacks so identified. Programs are suggested to foster improved medical care availability and early detection for those with sickle cell anemia. It is suggested that mandatory patient programs be avoided, and that research receive greater emphasis.

摘要

最近,镰状血红蛋白病问题的重点是对黑人进行大规模筛查。对镰状细胞性状本身所谓危险的担忧被作为部分理由提出。这种危险存在争议,有人提出镰状细胞性状为良性状态,而对被认定为此种性状的黑人可能造成严重社会危害的观点。建议开展相关项目,以提高对镰状细胞贫血患者的医疗服务可及性并实现早期检测。建议避免实施强制性患者项目,并应更加重视研究。

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本文引用的文献

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ABNORMAL HEMOGLOBINS AND PREGNANCY.异常血红蛋白与妊娠
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SICKLE CELL TRAIT AND SUPERIOR LONGITUDINAL SINUS THROMBOSIS.
Ann Intern Med. 1964 Mar;60:465-70. doi: 10.7326/0003-4819-60-3-465.
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Treatment of priapism: comparison of methods in fifteen cases.
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Sickle-cell trait and splenic infarction associated with high-altitude flying.
N Engl J Med. 1954 Sep 9;251(11):417-20. doi: 10.1056/NEJM195409092511102.
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Clinical triad of massive splenic infarction, sicklemia trait, and high altitude flying.
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