琥珀酰新制癌菌素的制备。
Preparation of succinyl neocarzinostatin.
作者信息
Maeda H
出版信息
Antimicrob Agents Chemother. 1974 Mar;5(3):354-5. doi: 10.1128/AAC.5.3.354.
Abstract
All amino groups in a proteinous antitumor antibiotic, neocarzinostatin, were reacted with succinic anhydride yielding bis-N-succinyl neocarzinostatin which retained biological activity in vitro against human cell lines and a bacterium. Amino groups in neocarzinostatin do not appear to play an important role in the activity.
摘要
蛋白质类抗肿瘤抗生素新制癌菌素中的所有氨基与琥珀酸酐反应，生成双 -N-琥珀酰新制癌菌素，其在体外对人细胞系和一种细菌仍保留生物活性。新制癌菌素中的氨基似乎在活性方面不发挥重要作用。
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1
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Biochim Biophys Acta. 1967 Feb 21;133(2):369-70. doi: 10.1016/0005-2795(67)90078-5.
3
Characterization of neocarzinostatin.新制癌菌素的特性分析。
J Antibiot (Tokyo). 1966 Nov;19(6):253-9.
4
Succinylation of pepsinogen.胃蛋白酶原的琥珀酰化作用。
J Biol Chem. 1967 Jun 10;242(11):2739-45.
5
Conformation of antibiotic protein, neocarzinostatin, studied by plane polarized infrared spectroscopy, circular dichroism and optical rotatory dispersion.通过平面偏振红外光谱、圆二色性和旋光色散研究抗生素蛋白新制癌菌素的构象。
Int J Pept Protein Res. 1973;5(1):19-26. doi: 10.1111/j.1399-3011.1973.tb02314.x.
6
Primary structure of neocarzinostatin, an antitumor protein.新制癌菌素的一级结构，一种抗肿瘤蛋白。
Science. 1972 Nov 24;178(4063):875-6. doi: 10.1126/science.178.4063.875.
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Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.长期培养中产生免疫球蛋白的人白血病和淋巴瘤细胞的克隆
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