Yoshitake T, Mizuno A, Saigusa M, Kato T
Ann Surg. 1974 Aug;180(2):203-8. doi: 10.1097/00000658-197408000-00013.
Plasma aldosterone concentration was measured in 11 cardiac patients after open cardiac surgery, by the radioimmunoassay method, and the relationship of it to electrolytes and acid-base balance of blood was analyzed. Plasma aldosterone concentration was markedly elevated in patients with low cardiac output, who required postoperative drip infusion of Isoproterenol, and in addition, both remarkable metabolic alkalosis and increase of potassium excretion in urine were confirmed in these patients. Plasma aldosterone concentration correlated significantly with potassium excretion in urine and was inversely related with potassium balance. However, plasma potassium concentration or arterial pH had no correlation to it. Approximately an inverse correlation was found between the logarithm of the sodium/potassium ratio in urine and plasma aldosterone concentration. These data indicate that aldosterone is an important factor which produces potassium depletion after open cardiac surgery.
采用放射免疫分析法对11例心脏直视手术后的心脏病患者测定血浆醛固酮浓度，并分析其与血液电解质及酸碱平衡的关系。心输出量低且术后需滴注异丙肾上腺素的患者，其血浆醛固酮浓度显著升高，此外，这些患者还出现了明显的代谢性碱中毒和尿钾排泄增加。血浆醛固酮浓度与尿钾排泄显著相关，与钾平衡呈负相关。然而，血浆钾浓度或动脉pH值与之无相关性。尿钠/钾比值的对数与血浆醛固酮浓度之间大致呈负相关。这些数据表明，醛固酮是心脏直视手术后导致钾缺乏的一个重要因素。
