Atkinson K, Kay H E, McElwain T J
Br Med J. 1974 Jul 20;3(5924):160-1. doi: 10.1136/bmj.3.5924.160.
A total of 100 consecutive episodes of fever of 101 degrees F (38.3 degrees C) or above in 56 neutropenic patients have been investigated. All the patients had either acute leukaemia or aplastic anaemia. A cause for the fever was found in 68 of these episodes, in 87% of which it was due to infection. The commonest single finding was septicaemia (30 episodes). Only two episodes of fever could be ascribed solely to the underlying malignant disease.Infection should be assumed to be present and the cause of fever in neutropenic patients until proved otherwise.
对56例中性粒细胞减少患者连续出现的100次体温达到101华氏度（38.3摄氏度）及以上的发热情况进行了调查。所有患者均患有急性白血病或再生障碍性贫血。在其中68次发热中发现了病因，其中87%是由感染引起的。最常见的单一发现是败血症（30次）。只有两次发热可完全归因于潜在的恶性疾病。在未证明其他情况之前，应假定中性粒细胞减少患者发热是由感染引起的。
