实验性猪痢疾结肠的电子显微镜检查变化
Electron microscopic changes in colon in experimental swine dysentery.
作者信息
Teige J, Nordstoga K
出版信息
Acta Vet Scand. 1979;20(2):224-37. doi: 10.1186/BF03546614.
Colonic lesions in experimental swine dysentery were studied electron microscopically. Changes indicative of stasis were commonly observed in the microcirculatory vessels of lamina propria. Early lesions in epithelial cells included sparse, short and irregular microvilli, swollen and degenerated mitochondria, and swelling and vesiculation of endoplasmatic reticulum. Numerous large spirochaetes were observed in these locations: a) in the crypts, b) free (i.e. not membrane bound) in cytoplasm of damaged epithelial cells, and c) in cavities, around vessels of lamina propria. It is suggested that stasis, and resultant disturbances in microcirculation in early developmental stages of swine dysentery, may play a pathogenetic role in the development of the necrotic colonic lesions. Finally, it is discussed whether a mechanism related to Sanarelli-Shwartzman reaction is implicated in the development of colonic lesions in swine dysentery.
对实验性猪痢疾的结肠病变进行了电子显微镜研究。在固有层的微循环血管中普遍观察到表明血流淤滞的变化。上皮细胞的早期病变包括稀疏、短小且不规则的微绒毛、肿胀和退化的线粒体以及内质网的肿胀和形成小泡。在这些部位观察到大量大螺旋体：a）在隐窝中，b）在受损上皮细胞的细胞质中游离（即不与膜结合），以及c）在固有层血管周围的腔中。有人提出，在猪痢疾早期发育阶段的血流淤滞以及由此导致的微循环紊乱，可能在坏死性结肠病变的发展中起致病作用。最后，讨论了与桑纳雷利 - 施瓦茨曼反应相关的机制是否与猪痢疾结肠病变的发展有关。
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