多巴胺和匹莫齐特对人绒毛膜促性腺激素分泌的体外作用。

In vitro effect of dopamine and pimozide on human chorionic gonadotropin secretion.

作者信息

Macaron C, Kyncl M, Famuyiwa O, Halpern B, Brewer J

出版信息

Am J Obstet Gynecol. 1979 Oct 15;135(4):499-502. doi: 10.1016/0002-9378(79)90439-3.

Abstract

In human placental explants cultured in vitro, dopamine inhibited human chorionic gonadotropin (hCG) secretion into the culture media. In the control flasks, the level of hCG secretion was 751 +/- 215 mIU/gm of tissue. When 1 mM of dopamine was added, hCG levels decreased to 321 +/- 57.6 mIU/gm of tissue (n = 6, P less than 0.1)--5 and 10 mM of dopamine significantly inhibited hCG secretion. In contrast, 1 mM of pimozide enhanced hCG secretion by 1.8-fold compared to control levels (1,707 +/- 343 versus 3,117 +/- 0.005). This in vitro effect on hCG is similar to the effect of dopamine and pimozide on hCS secretion by placental explants.

摘要

在体外培养的人胎盘外植体中，多巴胺抑制人绒毛膜促性腺激素（hCG）分泌到培养基中。在对照瓶中，hCG分泌水平为751±215 mIU/g组织。加入1 mM多巴胺后，hCG水平降至321±57.6 mIU/g组织（n = 6，P<0.1）——5 mM和10 mM多巴胺显著抑制hCG分泌。相比之下，与对照水平相比，1 mM匹莫齐特使hCG分泌增加了1.8倍（1707±343对3117±0.005）。这种对hCG的体外作用类似于多巴胺和匹莫齐特对胎盘外植体hCS分泌的作用。