小鼠肿瘤增强的定量研究。I. IgM、IgG1和IgG2诱导的肉瘤I增强。
Quantitative studies on tumor enhancement in mice. I. Enhancement of sarcoma I induced by IgM, IgG1, and IgG2.
作者信息
Rubinstein P, Decary F, Streun E W
出版信息
J Exp Med. 1974 Aug 1;140(2):591-6. doi: 10.1084/jem.140.2.591.
Abstract
The concentration of specific alloantibody in purified mouse immunoglobulin preparations was determined. When passively transferred in adequate doses, IgM, IgG1, and IgG2 antibodies all induced tumor enhancement in allogeneic hosts. IgM and IgG2 antibodies in high concentration led to inhibition of tumor growth. IgM and either IgG1 or IgG2 had additive effects on tumor enhancement. IgG1, but not IgG2, suppressed the inhibitory effect of IgM in high concentration.
摘要
测定了纯化的小鼠免疫球蛋白制剂中特异性同种抗体的浓度。当以适当剂量被动转移时，IgM、IgG1和IgG2抗体在同种异体宿主中均诱导肿瘤增强。高浓度的IgM和IgG2抗体导致肿瘤生长抑制。IgM与IgG1或IgG2对肿瘤增强有相加作用。IgG1而非IgG2抑制高浓度IgM的抑制作用。
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