随机临床试验中对高风险样本进行差别对待的心理影响。
The psychological effects of differential treatment of a high risk sample in a randomized clinical trial.
作者信息
Benfari R C, McIntyre K, Eaker E, Blumberg S, Paul O
出版信息
Am J Public Health. 1979 Oct;69(10):996-1000. doi: 10.2105/ajph.69.10.996.
A study was carried out using 616 participants in a randomized clinical trial at the Harvard MRFIT (Multiple Risk Factor Intervention Trial) Clinical Center, to test if there were differences in the psychological dimensions of anxiety, depression, and functional heart symptoms in groups given different levels of treatment in a CHD (Coronary Heart Disease) Intervention Program. A theoretical framework was given to justify a number of hypotheses as to the induction of adverse psychological effects. At the end of two years in the MRFIT Program there were no significant differences between the special intervention group (SI) and the usual care group (UC) in the selected psychological variables.
在哈佛多重危险因素干预试验（MRFIT）临床中心进行了一项随机临床试验，共有616名参与者。该试验旨在检验在冠心病（CHD）干预项目中，给予不同治疗水平的组在焦虑、抑郁和功能性心脏症状等心理维度上是否存在差异。给出了一个理论框架来证明一些关于诱发不良心理影响的假设。在MRFIT项目两年结束时，特殊干预组（SI）和常规护理组（UC）在所选心理变量上没有显著差异。
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