Byers R M, Krueger W W, Saxton J
Am J Surg. 1979 Oct;138(4):597-9. doi: 10.1016/0002-9610(79)90426-4.
Forty-seven patients with very advanced cancer of the pyriform sinus were treated with surgery and immediate postoperative radiation in a planned sequential manner. Eradication of the cancer above the clavicles was obtained in 81% of the patients, with a treatment mortality of 8%. Most of the patients' tumors were resected with primary closure, which obviated the need for complicated reconstructive procedures. The survival rate of 23% at 2 years and the high rate of distant metastasis reflect the aggressive biologic behavior of this cancer. The need to find an adjuvant treatment that will act upon the systemic spread of this cancer is obvious.
47例患有非常晚期梨状窦癌的患者接受了手术治疗，并在术后立即按计划顺序进行放疗。81%的患者锁骨以上的癌症得到根除，治疗死亡率为8%。大多数患者的肿瘤通过一期缝合切除，从而无需进行复杂的重建手术。2年生存率为23%，远处转移率高，反映了这种癌症具有侵袭性的生物学行为。显然需要找到一种能作用于这种癌症全身扩散的辅助治疗方法。
